{"id":4504,"date":"2024-01-18T21:57:57","date_gmt":"2024-01-18T21:57:57","guid":{"rendered":"http:\/\/wordpress.mytomorrows.com\/?p=4504"},"modified":"2024-02-27T13:25:27","modified_gmt":"2024-02-27T13:25:27","slug":"what-is-myotonic-dystrophy","status":"publish","type":"post","link":"https:\/\/main-portal.develop-mytomorrows.com\/ar\/blog\/patients\/what-is-myotonic-dystrophy\/","title":{"rendered":"What is Myotonic Dystrophy"},"content":{"rendered":"<p><span data-contrast=\"none\">Myotonic dystrophy (DM) is a genetic disorder characterized by progressive muscle wasting causing two main problems: muscles that don\u2019t relax quickly (myotonia) and that gradually get weaker over time. It<\/span><span data-contrast=\"auto\"> is a multi-system disorder, and symptoms can affect various organs and tissues, not just muscles. Performing daily activities<\/span><span data-contrast=\"none\"> can become challenging as this condition may also impact <\/span><span data-contrast=\"auto\">different <\/span><span data-contrast=\"none\">parts of the body, including the heart, lungs, digestive system, eyes, hormone-producing glands, and the brain, as well as the skeletal muscles.<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559740\":276}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">This is a progressive condition that may cause a wide range of health issues as it gradually worsens over time. The progression of myotonic dystrophy can vary widely among individuals, and it is difficult to predict the exact course of the disease for a specific person. <\/span><span data-contrast=\"auto\">Navigating myotonic dystrophy <\/span><span data-contrast=\"none\">can be complex, necessitating a personalized approach for each individual.\u00a0<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559740\":276}\">\u00a0<\/span><\/p>\n<h3 aria-level=\"3\"><strong>Types of Myotonic Dystrophy \u00a0<\/strong><\/h3>\n<p><span data-contrast=\"none\">There are two main types of myotonic dystrophy: Type 1 myotonic dystrophy (DM1) and Type 2 myotonic dystrophy (DM2).\u00a0<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559740\":276}\">\u00a0<\/span><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"13\" data-list-defn-props=\"{\"335552541\":1,\"335559684\":-2,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">DM1, also known as Steinert\u2019s disease, is the most common type. It can manifest at almost any age, but typically <\/span><span data-contrast=\"none\">it manifests in adulthood. Symptoms may include muscle weakness (particularly in the face, neck, hands, and feet), myotonia (difficulty relaxing muscles after contraction), cataracts, heart issues, hormone imbalances, and intellectual disabilities in some cases.<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559740\":276}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li data-leveltext=\"o\" data-font=\"Courier New\" data-listid=\"13\" data-list-defn-props=\"{\"335552541\":1,\"335559684\":-2,\"335559685\":1440,\"335559991\":360,\"469769226\":\"Courier New\",\"469769242\":[9675],\"469777803\":\"left\",\"469777804\":\"o\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"2\"><span data-contrast=\"none\">Congenital myotonic dystrophy is a variation of DM1 presenting in newborns, characterized by muscle weakness, respiratory problems, and developmental issues.<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559740\":276}\">\u00a0<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"13\" data-list-defn-props=\"{\"335552541\":1,\"335559684\":-2,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"none\">DM2: This type<\/span><span data-contrast=\"auto\"> is usually less severe than DM1 and has a later onset. Its symptoms are similar but tend to be milder and progress more slowly. It tends to affect muscles in the shoulder, elbows and hips.<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559740\":276}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><span data-contrast=\"none\">Both types of myotonic dystrophy result from genetic mutations that disrupt how certain proteins work in cells. And both can affect multiple body systems, resulting in a wide range of symptoms that extend beyond muscle-related issues.<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559740\":276}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Due to this complexity, this blog will focus on the more common type of myotonic dystrophy, DM1.<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559740\":276}\">\u00a0<\/span><\/p>\n<h3 aria-level=\"3\"><b><span data-contrast=\"none\">Symptoms of DM1<\/span><\/b><span data-ccp-props=\"{\"134245418\":true,\"134245529\":true,\"201341983\":0,\"335559738\":320,\"335559739\":80,\"335559740\":276}\">\u00a0<\/span><\/h3>\n<p><span data-contrast=\"none\">DM1 varies widely from person to person, affecting many body parts and causing many symptoms. Some people with myotonic dystrophy might have more serious muscle problems, while others might experience additional symptoms like learning difficulties or mood changes. There may also be other psychological challenges, for example feeling a lack of motivation after developing blurry vision due to cataracts, or patients can experience difficulties with mood and memory. The cardiac muscles, vital for heart function, might develop irregularities, which can cause symptoms like dizziness due to abnormal heart rhythms.\u00a0 If involuntary muscles are affected, it can lead to a range of issues: digestive problems such as constipation or indigestion, circulation challenges due to dysfunctional blood vessels, and breathing difficulties resulting from compromised control of the airways. <\/span><span data-contrast=\"auto\">This complexity underscores the need for a personalized approach to care.<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559740\":276}\">\u00a0<\/span><\/p>\n<h3 aria-level=\"3\"><b><span data-contrast=\"none\">Diagnosis and Genetic Testing <\/span><\/b><span data-ccp-props=\"{\"134245418\":true,\"134245529\":true,\"201341983\":0,\"335559738\":320,\"335559739\":80,\"335559740\":276}\">\u00a0<\/span><\/h3>\n<p><span data-contrast=\"none\">To diagnose myotonic dystrophy in general, doctors typically begin by doing a physical examination. They look for characteristic symptoms such as muscle weakness, myotonia, and cataracts. The next step is genetic testing to determine the type of myotonic dystrophy. This involves checking for specific gene mutations, in the DMPK gene (Dystrophia Myotonica Protein Kinase) for DM1, and in the CNBP gene (Cellular Nucleic Acid Binding Protein, also known as ZNF9, which stands for Zinc Finger Protein 9) for DM2. <\/span><span data-ccp-props=\"{\"201341983\":0,\"335559685\":-20,\"335559737\":-20,\"335559740\":276}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Imagine the genetic code as a long, complex instruction manual for building and maintaining the human body. In myotonic dystrophy, there\u2019s a section in this manual (the DNA) where a phrase is mistakenly repeated many times, leading to faulty instructions. The repeated phrase is an abnormal repetition of DNA building blocks in a particular gene.<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559685\":-20,\"335559737\":-20,\"335559740\":276}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Normally, this sequence of building DNA building blocks is repeated a few times in everyone\u2019s DNA, but in people with DM1, this sequence is repeated far more. The number of these repeats can vary greatly among individuals with DM1. Research is beginning to suggest that the higher the number of these repeats a person has, the more severe their symptoms may be and the earlier the disease may appear.<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559685\":-20,\"335559737\":-20,\"335559740\":276}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">For someone with DM1, genetic testing may not only confirm their diagnosis but may also suggest how future generations may be impacted by the disease. When a person with DM1 has children, the number of repeats is expected to increase in the next generation. As a result, the child may develop symptoms of the disease earlier and more severely than the parent did. This trend of increasing severity and earlier onset in each successive generation is referred to as \u201canticipation.\u201d People receiving a diagnosis may be referred to genetic counselling for more information and support.<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559685\":-20,\"335559737\":-20,\"335559740\":276}\">\u00a0<\/span><\/p>\n<h3 aria-level=\"3\"><b><span data-contrast=\"none\">Daily Challenges with Myotonic Dystrophy\u00a0<\/span><\/b><span data-ccp-props=\"{\"134245418\":true,\"134245529\":true,\"201341983\":0,\"335559738\":320,\"335559739\":80,\"335559740\":276}\">\u00a0<\/span><\/h3>\n<p><span data-contrast=\"none\">A study exploring the lived experience of people with various types of DM found the most common complaints overall were muscle weakness, fatigue, and daytime sleepiness. For people with DM1, the most challenging daily life activities were going up and down stairs, standing, and maintaining balance.\u00a0 Living with myotonic dystrophy involves adapting daily routines to manage progressive symptoms like muscle weakness and stiffness, which impact activities and independence. For example, scheduling regular breaks or time to rest may be one way to adapt. Another challenge people with DM1 may face is cognitive changes such as memory and concentration difficulties, leading to stress and frustration. These daily life changes may feel like a loss of independence and increased reliance on others. Depending on the needs, support is in most cases available.<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559740\":276}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Caregivers can support with daily tasks, like medication management and\/or transportation. C<\/span><span data-contrast=\"none\">ounselling, patient advocacy groups, and support groups may be helpful resources in learning to navigate these life changes. <\/span><span data-contrast=\"none\">Support may also come from family and friends. Finding a space to share experiences and learning coping strategies help both patients and caregivers as they adjust.<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559740\":276}\">\u00a0<\/span><\/p>\n<h3 aria-level=\"3\"><b><span data-contrast=\"none\">Treatment\u00a0<\/span><\/b><span data-ccp-props=\"{\"134245418\":true,\"134245529\":true,\"201341983\":0,\"335559738\":320,\"335559739\":80,\"335559740\":276}\">\u00a0<\/span><\/h3>\n<p><span data-contrast=\"none\">There is currently no cure for myotonic dystrophy. The approach to treatment places a focus on alleviating its symptoms. DM1 has a greater impact on various body systems and requires specialized care and monitoring. Therefore, clinical recommendations emphasize a comprehensive approach. Usually, a team of experts from different medical fields is necessary to manage the wide-ranging symptoms of DM1. They focus on understanding the disease\u2019s progression and adapting care accordingly. <\/span><br \/>\n<span data-contrast=\"none\">DM1 can be categorized into two main groups:<\/span><\/p>\n<p><strong>Clinical Recommendations for Severe Symptoms and Conditions:\u00a0<\/strong><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"2\" data-list-defn-props=\"{\"335552541\":1,\"335559684\":-2,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\">Skeletal Muscle Weakness and Rehabilitation:<\/span><span data-contrast=\"none\"> Regular evaluations and referrals to specialists like physical therapists and occupational therapists.<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559740\":276}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"2\" data-list-defn-props=\"{\"335552541\":1,\"335559684\":-2,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"none\">Skeletal Muscle Myotonia:<\/span><span data-contrast=\"none\"> Treatment options for muscle stiffness and pain.<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559740\":276}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"2\" data-list-defn-props=\"{\"335552541\":1,\"335559684\":-2,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"none\">Ocular Symptoms<\/span><span data-contrast=\"none\">: Managing eye conditions like cataracts and recommending annual eye exams.<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559740\":276}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"2\" data-list-defn-props=\"{\"335552541\":1,\"335559684\":-2,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"4\" data-aria-level=\"1\"><span data-contrast=\"none\">Gastrointestinal Symptoms<\/span><span data-contrast=\"none\">: Addressing digestive issues and recommending dietary adjustments and medications.<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559740\":276}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"2\" data-list-defn-props=\"{\"335552541\":1,\"335559684\":-2,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"5\" data-aria-level=\"1\"><span data-contrast=\"none\">Neuropsychiatric Symptoms<\/span><span data-contrast=\"none\">: Cognitive and behavioral assessments and referrals to mental health professionals.<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559740\":276}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"2\" data-list-defn-props=\"{\"335552541\":1,\"335559684\":-2,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"6\" data-aria-level=\"1\"><span data-contrast=\"none\">Psychosocial Symptoms<\/span><span data-contrast=\"none\">: Assessing social circumstances and referring to support services.<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559740\":276}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"2\" data-list-defn-props=\"{\"335552541\":1,\"335559684\":-2,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"7\" data-aria-level=\"1\"><span data-contrast=\"none\">Excessive Daytime Sleepiness (EDS)<\/span><span data-contrast=\"none\">: Evaluating and treating sleep-related issues.<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559740\":276}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"2\" data-list-defn-props=\"{\"335552541\":1,\"335559684\":-2,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"8\" data-aria-level=\"1\"><span data-contrast=\"none\">Endocrine and Metabolic Symptoms:<\/span><span data-contrast=\"none\"> Monitoring and managing conditions like diabetes and thyroid disorders.<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559740\":276}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"2\" data-list-defn-props=\"{\"335552541\":1,\"335559684\":-2,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"9\" data-aria-level=\"1\"><span data-contrast=\"none\">Tumors<\/span><span data-contrast=\"none\">: Detection and management of skin tumors and following cancer screening guidelines.\u00a0<\/span><\/li>\n<\/ul>\n<p><strong>Clinical Recommendations for Life-Threatening Symptoms:\u00a0<\/strong><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"2\" data-list-defn-props=\"{\"335552541\":1,\"335559684\":-2,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"10\" data-aria-level=\"1\"><span data-contrast=\"none\">Surgery, Anesthesia, and Pain<\/span><span data-contrast=\"none\">: Managing anesthesia risks and adverse reactions to medications specific to patients with DM1.<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559740\":276}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"2\" data-list-defn-props=\"{\"335552541\":1,\"335559684\":-2,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"11\" data-aria-level=\"1\"><span data-contrast=\"none\">Respiratory Symptoms<\/span><span data-contrast=\"none\">: Monitoring and managing respiratory complications.<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559740\":276}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"2\" data-list-defn-props=\"{\"335552541\":1,\"335559684\":-2,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\">Cardiovascular Symptoms:<\/span><span data-contrast=\"none\"> Addressing cardiac complications like arrhythmias and conducting routine cardiac evaluations.<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559740\":276}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"2\" data-list-defn-props=\"{\"335552541\":1,\"335559684\":-2,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"none\">Pregnancy and Obstetric Management<\/span><span data-contrast=\"none\">: Special care for women with DM1 during pregnancy and delivery, including genetic counselling.<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559740\":276}\"><br \/>\n<\/span><\/li>\n<\/ul>\n<p aria-level=\"3\"><b><span data-contrast=\"none\">Research Exploring New Treatment Options<\/span><\/b><span data-ccp-props=\"{\"134245418\":true,\"134245529\":true,\"201341983\":0,\"335559738\":320,\"335559739\":80,\"335559740\":276}\">\u00a0<\/span><\/p>\n<p aria-level=\"3\"><span data-contrast=\"none\">Research on myotonic dystrophy is exploring new ways to tackle the disease\u2019s genetic roots. These treatments are experimental and need more research to ensure they are safe and effective. They share a common goal: addressing the underlying genetic cause of myotonic dystrophy.<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559740\":276}\">\u00a0<\/span><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"2\" data-list-defn-props=\"{\"335552541\":1,\"335559684\":-2,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"none\">Gene Therapy<\/span><span data-contrast=\"none\">: This method focuses on either fixing or replacing the specific genes that are faulty in myotonic dystrophy, like repairing or substituting a broken part in a machine.<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559740\":276}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"2\" data-list-defn-props=\"{\"335552541\":1,\"335559684\":-2,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"4\" data-aria-level=\"1\"><span data-contrast=\"none\">Antisense Oligonucleotides (ASOs)<\/span><span data-contrast=\"none\">: Designed to act like a sticky note placed over a mistake to cover it up and prevent the machine from reading the faulty instructions.<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559740\":276}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"2\" data-list-defn-props=\"{\"335552541\":1,\"335559684\":-2,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"5\" data-aria-level=\"1\"><span data-contrast=\"none\">RNA-mediated Therapies<\/span><span data-contrast=\"none\">: These act like specialized inspectors who go through the instruction manual to find the misprints and either fix them or remove them to ensure the machine runs smoothly.<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559740\":276}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"2\" data-list-defn-props=\"{\"335552541\":1,\"335559684\":-2,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"6\" data-aria-level=\"1\"><span data-contrast=\"none\">Small Molecule Drugs<\/span><span data-contrast=\"none\">: Suppose a misprint in the instruction manual is causing the gears (muscles) to function improperly. An example analogy of this type of treatment is like a special oil. It doesn\u2019t rewrite the instruction manual, but it may help the gears work more smoothly.<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559740\":276}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"2\" data-list-defn-props=\"{\"335552541\":1,\"335559684\":-2,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}\" aria-setsize=\"-1\" data-aria-posinset=\"7\" data-aria-level=\"1\"><span data-contrast=\"none\">CRISPR\/Cas9 Technology<\/span><span data-contrast=\"none\">: This technique edits the gene directly to correct the mistake, like editing a typo in the instruction manual.<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559740\":276}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><span data-contrast=\"none\">While their end goal is similar, each approach works at a different stage or aspect of the genetic problem in myotonic dystrophy. This diversity in approaches is important to help increase the chances of finding effective treatments for the condition.<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559740\":276}\">\u00a0<\/span><\/p>\n<h3 aria-level=\"3\"><b><span data-contrast=\"none\">Conclusion <\/span><\/b><span data-ccp-props=\"{\"134245418\":true,\"134245529\":true,\"201341983\":0,\"335559738\":320,\"335559739\":80,\"335559740\":276}\">\u00a0<\/span><\/h3>\n<p><span data-contrast=\"none\">Myotonic dystrophy, a complex genetic disorder, has varied manifestations and requires a multi-faceted approach for diagnosis, treatment, and daily management. The process of diagnosing myotonic dystrophy involves a physical examination followed by genetic testing. Understanding the implications of a positive diagnosis, including the likelihood of passing myotonic dystrophy through inheritance, is important.\u00a0<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559740\":276}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Living with myotonic dystrophy involves a continuous process of adaptation to manage an evolving set of symptoms, impacting both physical and emotional aspects of life for patients and their caregivers. Staying informed and proactive is key for patients and their families in navigating this condition.\u00a0<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559740\":276}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">myTomorrows is dedicated to helping patients with myotonic dystrophy. We can support with finding and if patients wish so, help with accessing clinical trials. <a href=\"\/contact-patients\/\">Click here<\/a> to get started and speak with one of our patient navigators.<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559740\":276}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">The information in this blog is not intended as a substitute for a medical consultation. Always consult a doctor before receiving a diagnosis or treatment.<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559740\":276}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">The myTomorrows team<\/span><br \/>\n<span data-contrast=\"auto\">Anthony Fokkerweg 61-2<\/span><br \/>\n<span data-contrast=\"auto\">1059CP Amsterdam<\/span><br \/>\n<span data-contrast=\"auto\">The Netherlands<\/span><span data-ccp-props=\"{\"201341983\":0,\"335559740\":276}\">\u00a0<\/span><\/p>\n<p>\u00a0<\/p>\n<div class=\"gmail-OutlineElement gmail-Ltr gmail-SCXW109579805 gmail-BCX0\">\n<p class=\"gmail-Paragraph gmail-SCXW109579805 gmail-BCX0\"><em><b><u><span class=\"gmail-TextRun gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">References<\/span><\/span><span class=\"gmail-EOP gmail-SCXW109579805 gmail-BCX0\">\u00a0<\/span><\/u><\/b><\/em><\/p>\n<\/div>\n<div class=\"gmail-OutlineElement gmail-Ltr gmail-SCXW109579805 gmail-BCX0\">\n<p class=\"gmail-Paragraph gmail-SCXW109579805 gmail-BCX0\"><em><span class=\"gmail-TextRun gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Hagerman KA, Howe SJ, <\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Heatwole<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> CR. The myotonic dystrophy experience: a North American cross<\/span><\/span><span class=\"gmail-TextRun gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">\u2010<\/span><\/span><span class=\"gmail-TextRun gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">sectional study. Muscle Nerve. 2019 Apr;59(4):457\u201364.<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> Available from: <\/span><\/span><\/em><em><a class=\"gmail-Hyperlink gmail-SCXW109579805 gmail-BCX0\" title=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6590656\/\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6590656\/\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"gmail-TextRun gmail-Underlined gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6590656\/<\/span><\/span><\/a><span class=\"gmail-EOP gmail-SCXW109579805 gmail-BCX0\">\u00a0<\/span><\/em><\/p>\n<\/div>\n<div class=\"gmail-OutlineElement gmail-Ltr gmail-SCXW109579805 gmail-BCX0\">\n<p class=\"gmail-Paragraph gmail-SCXW109579805 gmail-BCX0\"><em><span class=\"gmail-TextRun gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Myotonic Muscular Dystrophy [Internet]. [cited 2023 Dec 21]. Available from: <\/span><\/span><a class=\"gmail-Hyperlink gmail-SCXW109579805 gmail-BCX0\" title=\"https:\/\/www.hopkinsmedicine.org\/neurology-neurosurgery\/specialty-areas\/muscular-dystrophy\/myotonic-muscular-dystrophy\" href=\"https:\/\/www.hopkinsmedicine.org\/neurology-neurosurgery\/specialty-areas\/muscular-dystrophy\/myotonic-muscular-dystrophy\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"gmail-TextRun gmail-Underlined gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">https:\/\/www.hopkinsmedicine.org\/neurology-neurosurgery\/specialty-areas\/muscular-dystrophy\/myotonic-muscular-dystrophy<\/span><\/span><\/a><span class=\"gmail-EOP gmail-SCXW109579805 gmail-BCX0\">\u00a0<\/span><\/em><\/p>\n<\/div>\n<div class=\"gmail-OutlineElement gmail-Ltr gmail-SCXW109579805 gmail-BCX0\">\n<p class=\"gmail-Paragraph gmail-SCXW109579805 gmail-BCX0\"><em><span class=\"gmail-TextRun gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Heatwole<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> C, Bode R, Johnson N, Quinn C, Martens W, McDermott MP, et al. Patient-reported impact of symptoms in myotonic dystrophy type 1 (PRISM-1). Neurology. 2012 Jul 24;79(4):348\u201357. <\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Available from: <\/span><\/span><a class=\"gmail-Hyperlink gmail-SCXW109579805 gmail-BCX0\" title=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22786587\/\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22786587\/\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"gmail-TextRun gmail-Underlined gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">https:\/\/pubmed.ncbi.nlm.nih.gov\/22786587\/<\/span><\/span><\/a><span class=\"gmail-EOP gmail-SCXW109579805 gmail-BCX0\">\u00a0<\/span><\/em><\/p>\n<\/div>\n<div class=\"gmail-OutlineElement gmail-Ltr gmail-SCXW109579805 gmail-BCX0\">\n<p class=\"gmail-Paragraph gmail-SCXW109579805 gmail-BCX0\"><em><span class=\"gmail-TextRun gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Meola<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> G, <\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Cardani<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> R. Myotonic Dystrophy Type 2: An Update on Clinical Aspects, Genetic and Pathomolecular Mechanism. J <\/span><span class=\"gmail-NormalTextRun gmail-SpellingErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">Neuromuscul<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> Dis. 2015 Jul 22;2(Suppl 2<\/span><span class=\"gmail-NormalTextRun gmail-ContextualSpellingAndGrammarErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">):S<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">59\u201371.<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> Available from:<\/span><\/span><span class=\"gmail-LineBreakBlob gmail-BlobObject gmail-DragDrop gmail-SCXW109579805 gmail-BCX0\"><span class=\"gmail-SCXW109579805 gmail-BCX0\">\u00a0<\/span><br class=\"gmail-SCXW109579805 gmail-BCX0\" \/><\/span><a class=\"gmail-Hyperlink gmail-SCXW109579805 gmail-BCX0\" title=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27858759\/\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27858759\/\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"gmail-TextRun gmail-Underlined gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">https:\/\/pubmed.ncbi.nlm.nih.gov\/27858759\/<\/span><\/span><\/a><span class=\"gmail-EOP gmail-SCXW109579805 gmail-BCX0\">\u00a0<\/span><\/em><\/p>\n<\/div>\n<div class=\"gmail-OutlineElement gmail-Ltr gmail-SCXW109579805 gmail-BCX0\">\n<p class=\"gmail-Paragraph gmail-SCXW109579805 gmail-BCX0\"><em><span class=\"gmail-TextRun gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">De Antonio M, Dogan C, <\/span><span class=\"gmail-NormalTextRun gmail-SpellingErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">Daidj<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> F, <\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Eymard<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> B, <\/span><span class=\"gmail-NormalTextRun gmail-SpellingErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">Puymirat<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> J, Mathieu J, et al. The DM-scope registry: a rare disease innovative framework bridging the gap between research and medical care. <\/span><span class=\"gmail-NormalTextRun gmail-SpellingErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">Orphanet<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> J Rare Dis. 2019 Jun 3;14(1):122.<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> Available from: <\/span><\/span><a class=\"gmail-Hyperlink gmail-SCXW109579805 gmail-BCX0\" title=\"https:\/\/ojrd.biomedcentral.com\/articles\/10.1186\/s13023-019-1088-3\" href=\"https:\/\/ojrd.biomedcentral.com\/articles\/10.1186\/s13023-019-1088-3\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"gmail-TextRun gmail-Underlined gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">https:\/\/ojrd.biomedcentral.com\/articles\/10.1186\/s13023-019-1088-3<\/span><\/span><\/a><span class=\"gmail-EOP gmail-SCXW109579805 gmail-BCX0\">\u00a0<\/span><\/em><\/p>\n<\/div>\n<div class=\"gmail-OutlineElement gmail-Ltr gmail-SCXW109579805 gmail-BCX0\">\n<p class=\"gmail-Paragraph gmail-SCXW109579805 gmail-BCX0\"><em><span class=\"gmail-TextRun gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Wood L, <\/span><span class=\"gmail-NormalTextRun gmail-SpellingErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">Bassez<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> G, <\/span><span class=\"gmail-NormalTextRun gmail-SpellingErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">Bleyenheuft<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> C, Campbell C, Cossette L, Jimenez-Moreno AC, et al. Eight years after an international workshop on myotonic dystrophy patient registries: case study of a global collaboration for a rare disease. <\/span><span class=\"gmail-NormalTextRun gmail-SpellingErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">Orphanet<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> J Rare Dis. 2018 Sep 5;13(1):155.<\/span><\/span><a class=\"gmail-Hyperlink gmail-SCXW109579805 gmail-BCX0\" title=\"https:\/\/ojrd.biomedcentral.com\/articles\/10.1186\/s13023-018-0889-0\" href=\"https:\/\/ojrd.biomedcentral.com\/articles\/10.1186\/s13023-018-0889-0\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"gmail-TextRun gmail-Underlined gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">https:\/\/ojrd.biomedcentral.com\/articles\/10.1186\/s13023-018-0889-0<\/span><\/span><\/a><span class=\"gmail-EOP gmail-SCXW109579805 gmail-BCX0\">\u00a0<\/span><\/em><\/p>\n<\/div>\n<div class=\"gmail-OutlineElement gmail-Ltr gmail-SCXW109579805 gmail-BCX0\">\n<p class=\"gmail-Paragraph gmail-SCXW109579805 gmail-BCX0\"><em><span class=\"gmail-TextRun gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Norwood FLM, Harling C, Chinnery PF, Eagle M, Bushby K, Straub V. Prevalence of genetic muscle disease in Northern England: in-depth analysis of a muscle clinic population. Brain. 2009 Nov 1;132(11):3175\u201386.<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> Available from: <\/span><\/span><a class=\"gmail-Hyperlink gmail-SCXW109579805 gmail-BCX0\" title=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19767415\/\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19767415\/\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"gmail-TextRun gmail-Underlined gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">https:\/\/pubmed.ncbi.nlm.nih.gov\/19767415\/<\/span><\/span><\/a><span class=\"gmail-EOP gmail-SCXW109579805 gmail-BCX0\">\u00a0<\/span><\/em><\/p>\n<\/div>\n<div class=\"gmail-OutlineElement gmail-Ltr gmail-SCXW109579805 gmail-BCX0\">\n<p class=\"gmail-Paragraph gmail-SCXW109579805 gmail-BCX0\"><em><span class=\"gmail-TextRun gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">De Antonio M, Dogan C, <\/span><span class=\"gmail-NormalTextRun gmail-SpellingErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">Hamroun<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> D, Mati M, <\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Zerrouki<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> S, <\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Eymard<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> B, et al. Unravelling the myotonic dystrophy type 1 clinical spectrum: A systematic registry-based study with implications for disease classification. Rev Neurol (Paris). 2016 Oct;172(10):572\u201380.<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> Available from: <\/span><\/span><a class=\"gmail-Hyperlink gmail-SCXW109579805 gmail-BCX0\" title=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27665240\/\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27665240\/\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"gmail-TextRun gmail-Underlined gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">https:\/\/pubmed.ncbi.nlm.nih.gov\/27665240\/<\/span><\/span><\/a><span class=\"gmail-EOP gmail-SCXW109579805 gmail-BCX0\">\u00a0<\/span><\/em><\/p>\n<\/div>\n<div class=\"gmail-OutlineElement gmail-Ltr gmail-SCXW109579805 gmail-BCX0\">\n<p class=\"gmail-Paragraph gmail-SCXW109579805 gmail-BCX0\"><em><span class=\"gmail-TextRun gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"><a title=\"https:\/\/fyra.io\" href=\"https:\/\/fyra.io\">https:\/\/fyra.io<\/a>. Practical Neurology. Bryn <\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Mawr<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> Communications; [cited 2023 Dec 22]. Noninflammatory Myopathies. Available from: <\/span><\/span><a class=\"gmail-Hyperlink gmail-SCXW109579805 gmail-BCX0\" title=\"https:\/\/practicalneurology.com\/articles\/2019-aug-july\/noninflammatory-myopathies\" href=\"https:\/\/practicalneurology.com\/articles\/2019-aug-july\/noninflammatory-myopathies\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"gmail-TextRun gmail-Underlined gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">https:\/\/practicalneurology.com\/articles\/2019-aug-july\/noninflammatory-myopathies<\/span><\/span><\/a><span class=\"gmail-EOP gmail-SCXW109579805 gmail-BCX0\">\u00a0<\/span><\/em><\/p>\n<\/div>\n<div class=\"gmail-OutlineElement gmail-Ltr gmail-SCXW109579805 gmail-BCX0\">\n<p class=\"gmail-Paragraph gmail-SCXW109579805 gmail-BCX0\"><em><span class=\"gmail-TextRun gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Bird TD. Myotonic Dystrophy Type 1. In: Adam MP, Feldman J, <\/span><span class=\"gmail-NormalTextRun gmail-SpellingErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">Mirzaa<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> GM, <\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Pagon<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> RA, Wallace SE, Bean LJ, et al., editors. <\/span><span class=\"gmail-NormalTextRun gmail-SpellingErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">GeneReviews<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">\u00ae [Internet]. Seattle (WA): University of Washington, Seattle; 1993 [cited 2023 Dec 21]. Available from: <\/span><\/span><a class=\"gmail-Hyperlink gmail-SCXW109579805 gmail-BCX0\" title=\"http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1165\/\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1165\/\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"gmail-TextRun gmail-Underlined gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1165\/<\/span><\/span><\/a><span class=\"gmail-EOP gmail-SCXW109579805 gmail-BCX0\">\u00a0<\/span><\/em><\/p>\n<\/div>\n<div class=\"gmail-OutlineElement gmail-Ltr gmail-SCXW109579805 gmail-BCX0\">\n<p class=\"gmail-Paragraph gmail-SCXW109579805 gmail-BCX0\"><em><span class=\"gmail-TextRun gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SpellingErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">Khoshbakht<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> R, <\/span><span class=\"gmail-NormalTextRun gmail-SpellingErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">Soltanzadeh<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> A, Zamani B, Abdi S, <\/span><span class=\"gmail-NormalTextRun gmail-SpellingErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">Gharagozli<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> K, <\/span><span class=\"gmail-NormalTextRun gmail-SpellingErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">Kahrizi<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> K, et al. Correlation between distribution of muscle weakness, electrophysiological findings and CTG expansion in myotonic dystrophy. J Clin <\/span><span class=\"gmail-NormalTextRun gmail-SpellingErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">Neurosci<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> Off J <\/span><span class=\"gmail-NormalTextRun gmail-SpellingErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">Neurosurg<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> Soc <\/span><span class=\"gmail-NormalTextRun gmail-SpellingErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">Australas<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">. 2014 Jul;21(7):1123\u20136.<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> Available from: <\/span><\/span><a class=\"gmail-Hyperlink gmail-SCXW109579805 gmail-BCX0\" title=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24417793\/\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24417793\/\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"gmail-TextRun gmail-Underlined gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">https:\/\/pubmed.ncbi.nlm.nih.gov\/24417793\/<\/span><\/span><\/a><span class=\"gmail-EOP gmail-SCXW109579805 gmail-BCX0\">\u00a0<\/span><\/em><\/p>\n<\/div>\n<div class=\"gmail-OutlineElement gmail-Ltr gmail-SCXW109579805 gmail-BCX0\">\n<p class=\"gmail-Paragraph gmail-SCXW109579805 gmail-BCX0\"><em><span class=\"gmail-TextRun gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SpellingErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">Vydra<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> DG, <\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Rayi<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> A. Myotonic Dystrophy. In: <\/span><span class=\"gmail-NormalTextRun gmail-SpellingErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">StatPearls<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> [Internet]. Treasure Island (FL): <\/span><span class=\"gmail-NormalTextRun gmail-SpellingErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">StatPearls<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> Publishing; 2023 [cited 2023 Dec 21]. Available from: <\/span><\/span><a class=\"gmail-Hyperlink gmail-SCXW109579805 gmail-BCX0\" title=\"http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK557446\/\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK557446\/\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"gmail-TextRun gmail-Underlined gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK557446\/<\/span><\/span><\/a><span class=\"gmail-EOP gmail-SCXW109579805 gmail-BCX0\">\u00a0<\/span><\/em><\/p>\n<\/div>\n<div class=\"gmail-OutlineElement gmail-Ltr gmail-SCXW109579805 gmail-BCX0\">\n<p class=\"gmail-Paragraph gmail-SCXW109579805 gmail-BCX0\"><em><span class=\"gmail-TextRun gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">University of Rochester Medical Center. URMC Newsroom. 2015 [cited 2023 Dec 20]. Study Identifies Patients\u2019 Priorities in Treating Rare Muscular Dystrophy. Available from: <\/span><\/span><a class=\"gmail-Hyperlink gmail-SCXW109579805 gmail-BCX0\" title=\"https:\/\/www.urmc.rochester.edu\/news\/story\/study-identifies-patients-priorities-in-treating-rare-muscular-dystrophy\" href=\"https:\/\/www.urmc.rochester.edu\/news\/story\/study-identifies-patients-priorities-in-treating-rare-muscular-dystrophy\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"gmail-TextRun gmail-Underlined gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">https:\/\/www.urmc.rochester.edu\/news\/story\/study-identifies-patients-priorities-in-treating-rare-muscular-dystrophy<\/span><\/span><\/a><span class=\"gmail-EOP gmail-SCXW109579805 gmail-BCX0\">\u00a0<\/span><\/em><\/p>\n<\/div>\n<div class=\"gmail-OutlineElement gmail-Ltr gmail-SCXW109579805 gmail-BCX0\">\n<p class=\"gmail-Paragraph gmail-SCXW109579805 gmail-BCX0\"><em><span class=\"gmail-TextRun gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SpellingErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">Ashizawa<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> T, Gagnon C, Groh WJ, Gutmann L, Johnson NE, <\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Meola<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> G, et al. Consensus-based care recommendations for adults with myotonic dystrophy type 1. Neurol Clin <\/span><span class=\"gmail-NormalTextRun gmail-SpellingErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">Pract<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">. 2018 Dec;8(6):507\u201320.<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> Available from: <\/span><\/span><a class=\"gmail-Hyperlink gmail-SCXW109579805 gmail-BCX0\" title=\"https:\/\/www.neurology.org\/doi\/10.1212\/CPJ.0000000000000531\" href=\"https:\/\/www.neurology.org\/doi\/10.1212\/CPJ.0000000000000531\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"gmail-TextRun gmail-Underlined gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">https:\/\/www.neurology.org\/doi\/10.1212\/CPJ.0000000000000531<\/span><\/span><\/a><span class=\"gmail-EOP gmail-SCXW109579805 gmail-BCX0\">\u00a0<\/span><\/em><\/p>\n<\/div>\n<div class=\"gmail-OutlineElement gmail-Ltr gmail-SCXW109579805 gmail-BCX0\">\n<p class=\"gmail-Paragraph gmail-SCXW109579805 gmail-BCX0\"><em><span class=\"gmail-TextRun gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SpellingErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">Modoni<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> A, Silvestri G, Grazia <\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Pomponi<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> M, <\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Mangiola<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> F, <\/span><span class=\"gmail-NormalTextRun gmail-SpellingErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">Tonali<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> PA, <\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Marra<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> C. Characterization of the Pattern of Cognitive Impairment in Myotonic Dystrophy Type 1. Arch Neurol. 2004 Dec 1;61(12):1943\u20137.<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> Available from: <\/span><\/span><a class=\"gmail-Hyperlink gmail-SCXW109579805 gmail-BCX0\" title=\"https:\/\/jamanetwork.com\/journals\/jamaneurology\/fullarticle\/787358#:~:text=Results%20Our%20study%20documented%202,frontal%20and%20temporal%20cognitive%20functions\" href=\"https:\/\/jamanetwork.com\/journals\/jamaneurology\/fullarticle\/787358#:~:text=Results%20Our%20study%20documented%202,frontal%20and%20temporal%20cognitive%20functions\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"gmail-TextRun gmail-Underlined gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">https:\/\/jamanetwork.com\/journals\/jamaneurology\/fullarticle\/787358<\/span><\/span><\/a><\/em><\/p>\n<\/div>\n<div class=\"gmail-OutlineElement gmail-Ltr gmail-SCXW109579805 gmail-BCX0\">\n<p class=\"gmail-Paragraph gmail-SCXW109579805 gmail-BCX0\"><em><span class=\"gmail-TextRun gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Miller JN, Kruger A, Moser DJ, Gutmann L, van der <\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Plas<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> E, <\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Koscik<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> TR, et al. Cognitive Deficits, Apathy, and Hypersomnolence Represent the Core Brain Symptoms of Adult-Onset Myotonic Dystrophy Type 1. Front Neurol [Internet]. 2021 [cited 2023 Dec 20];12. Available from: <\/span><\/span><a class=\"gmail-Hyperlink gmail-SCXW109579805 gmail-BCX0\" title=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2021.700796\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2021.700796\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"gmail-TextRun gmail-Underlined gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2021.700796<\/span><\/span><\/a><span class=\"gmail-EOP gmail-SCXW109579805 gmail-BCX0\">\u00a0<\/span><\/em><\/p>\n<\/div>\n<div class=\"gmail-OutlineElement gmail-Ltr gmail-SCXW109579805 gmail-BCX0\">\n<p class=\"gmail-Paragraph gmail-SCXW109579805 gmail-BCX0\"><em><span class=\"gmail-TextRun gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">McNally EM, Mann DL, Pinto Y, Bhakta D, Tomaselli G, Nazarian S, et al. Clinical Care Recommendations for Cardiologists Treating Adults <\/span><span class=\"gmail-NormalTextRun gmail-ContextualSpellingAndGrammarErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">With<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Myotonic Dystrophy. J Am Heart Assoc Cardiovasc <\/span><span class=\"gmail-NormalTextRun gmail-SpellingErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">Cerebrovasc<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> Dis. 2020 Feb 6;9(4<\/span><span class=\"gmail-NormalTextRun gmail-ContextualSpellingAndGrammarErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">):e<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">014006.<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> Available from: <\/span><\/span><a class=\"gmail-Hyperlink gmail-SCXW109579805 gmail-BCX0\" title=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32067592\/\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32067592\/\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"gmail-TextRun gmail-Underlined gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">https:\/\/pubmed.ncbi.nlm.nih.gov\/32067592\/<\/span><\/span><\/a><span class=\"gmail-EOP gmail-SCXW109579805 gmail-BCX0\">\u00a0<\/span><\/em><\/p>\n<\/div>\n<div class=\"gmail-OutlineElement gmail-Ltr gmail-SCXW109579805 gmail-BCX0\">\n<p class=\"gmail-Paragraph gmail-SCXW109579805 gmail-BCX0\"><em><span class=\"gmail-TextRun gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Sunday MW|, April 8, 2012. Muscular Dystrophy Association. 2016 [cited 2023 Dec 20]. Quest \u2013 Article \u2013 Cardiac Care in MMD: Lack of Symptoms May Mask Deadly Problems. Available from: <\/span><\/span><a class=\"gmail-Hyperlink gmail-SCXW109579805 gmail-BCX0\" title=\"https:\/\/www.mda.org\/quest\/article\/cardiac-care-mmd-lack-of-symptoms-may-mask-deadly-problems\" href=\"https:\/\/www.mda.org\/quest\/article\/cardiac-care-mmd-lack-of-symptoms-may-mask-deadly-problems\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"gmail-TextRun gmail-Underlined gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">https:\/\/www.mda.org\/quest\/article\/cardiac-care-mmd-lack-of-symptoms-may-mask-deadly-problems<\/span><\/span><\/a><span class=\"gmail-EOP gmail-SCXW109579805 gmail-BCX0\">\u00a0<\/span><\/em><\/p>\n<\/div>\n<div class=\"gmail-OutlineElement gmail-Ltr gmail-SCXW109579805 gmail-BCX0\">\n<p class=\"gmail-Paragraph gmail-SCXW109579805 gmail-BCX0\"><em><span class=\"gmail-TextRun gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Geirdal<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> A\u00d8, Lund-Petersen I, Heiberg A. Understanding the Experience of Myotonic Dystrophy. Mixed Method Study. J Genet Couns. 2015;24(1):169\u201378.<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> Available from: <\/span><\/span><a class=\"gmail-Hyperlink gmail-SCXW109579805 gmail-BCX0\" title=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4297614\/\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4297614\/\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"gmail-TextRun gmail-Underlined gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4297614\/<\/span><\/span><\/a><span class=\"gmail-EOP gmail-SCXW109579805 gmail-BCX0\">\u00a0<\/span><\/em><\/p>\n<\/div>\n<div class=\"gmail-OutlineElement gmail-Ltr gmail-SCXW109579805 gmail-BCX0\">\n<p class=\"gmail-Paragraph gmail-SCXW109579805 gmail-BCX0\"><em><span class=\"gmail-TextRun gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Cup EH, <\/span><span class=\"gmail-NormalTextRun gmail-SpellingErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">Kin\u00e9banian<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> A, <\/span><span class=\"gmail-NormalTextRun gmail-SpellingErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">Satink<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> T, Pieterse AJ, Hendricks HT, <\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Oostendorp<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> RA, et al. Living with myotonic dystrophy; what can be learned from couples? a qualitative study. BMC Neurol. 2011 Jul 13;11(1):86.<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> Available from: <\/span><\/span><a class=\"gmail-Hyperlink gmail-SCXW109579805 gmail-BCX0\" title=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3158552\/\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3158552\/\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"gmail-TextRun gmail-Underlined gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3158552\/<\/span><\/span><\/a><span class=\"gmail-EOP gmail-SCXW109579805 gmail-BCX0\">\u00a0<\/span><\/em><\/p>\n<\/div>\n<div class=\"gmail-OutlineElement gmail-Ltr gmail-SCXW109579805 gmail-BCX0\">\n<p class=\"gmail-Paragraph gmail-SCXW109579805 gmail-BCX0\"><em><span class=\"gmail-TextRun gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Finsterer J, <\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Rudnik-<\/span><span class=\"gmail-NormalTextRun gmail-SpellingErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">Sch\u00f6neborn<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> S. [Myotonic dystrophies: clinical presentation, pathogenesis, <\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">diagnostics<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> and therapy]. <\/span><span class=\"gmail-NormalTextRun gmail-SpellingErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">Fortschr<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> Neurol <\/span><span class=\"gmail-NormalTextRun gmail-SpellingErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">Psychiatr<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">. 2015 Jan;83(1):9\u201317.<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> Available from: <\/span><\/span><a class=\"gmail-Hyperlink gmail-SCXW109579805 gmail-BCX0\" title=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25602187\/\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25602187\/\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"gmail-TextRun gmail-Underlined gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">https:\/\/pubmed.ncbi.nlm.nih.gov\/25602187\/<\/span><\/span><\/a><span class=\"gmail-EOP gmail-SCXW109579805 gmail-BCX0\">\u00a0<\/span><\/em><\/p>\n<\/div>\n<div class=\"gmail-OutlineElement gmail-Ltr gmail-SCXW109579805 gmail-BCX0\">\n<p class=\"gmail-Paragraph gmail-SCXW109579805 gmail-BCX0\"><em><span class=\"gmail-TextRun gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Muscular Dystrophy Association. Muscular Dystrophy Association. 2015 [cited 2023 Dec 20]. Causes\/Inheritance \u2013 Myotonic Dystrophy (DM) \u2013 Diseases. Available from: <\/span><\/span><a class=\"gmail-Hyperlink gmail-SCXW109579805 gmail-BCX0\" title=\"https:\/\/www.mda.org\/disease\/myotonic-dystrophy\/causes-inheritance\" href=\"https:\/\/www.mda.org\/disease\/myotonic-dystrophy\/causes-inheritance\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"gmail-TextRun gmail-Underlined gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">https:\/\/www.mda.org\/disease\/myotonic-dystrophy\/causes-inheritance<\/span><\/span><\/a><span class=\"gmail-EOP gmail-SCXW109579805 gmail-BCX0\">\u00a0<\/span><\/em><\/p>\n<\/div>\n<div class=\"gmail-OutlineElement gmail-Ltr gmail-SCXW109579805 gmail-BCX0\">\n<p class=\"gmail-Paragraph gmail-SCXW109579805 gmail-BCX0\"><em><span class=\"gmail-TextRun gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Muscular Dystrophy Association. Working With Your Myotonic Dystrophy Care Team | Myotonic Dystrophy Foundation [Internet]. 2023 [cited 2023 Dec 20]. Available from: <\/span><\/span><a class=\"gmail-Hyperlink gmail-SCXW109579805 gmail-BCX0\" title=\"https:\/\/www.myotonic.org\/working-your-myotonic-dystrophy-care-team\" href=\"https:\/\/www.myotonic.org\/working-your-myotonic-dystrophy-care-team\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"gmail-TextRun gmail-Underlined gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">https:\/\/www.myotonic.org\/working-your-myotonic-dystrophy-care-team<\/span><\/span><\/a><span class=\"gmail-EOP gmail-SCXW109579805 gmail-BCX0\">\u00a0<\/span><\/em><\/p>\n<\/div>\n<div class=\"gmail-OutlineElement gmail-Ltr gmail-SCXW109579805 gmail-BCX0\">\n<p class=\"gmail-Paragraph gmail-SCXW109579805 gmail-BCX0\"><em><span class=\"gmail-TextRun gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Pascual-<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Gilabert<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> M, <\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Artero<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> R, L\u00f3pez-Castel A. The myotonic dystrophy type 1 drug development pipeline: 2022 edition. Drug <\/span><span class=\"gmail-NormalTextRun gmail-SpellingErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">Discov<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> Today. 2023 Mar 1;28(3):103489.<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> Available from: <\/span><\/span><a class=\"gmail-Hyperlink gmail-SCXW109579805 gmail-BCX0\" title=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1359644623000053\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1359644623000053\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"gmail-TextRun gmail-Underlined gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1359644623000053<\/span><\/span><\/a><span class=\"gmail-EOP gmail-SCXW109579805 gmail-BCX0\">\u00a0<\/span><\/em><\/p>\n<\/div>\n<div class=\"gmail-OutlineElement gmail-Ltr gmail-SCXW109579805 gmail-BCX0\">\n<p class=\"gmail-Paragraph gmail-SCXW109579805 gmail-BCX0\"><em><span class=\"gmail-TextRun gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SpellingErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">Ait<\/span> <span class=\"gmail-NormalTextRun gmail-SpellingErrorV2Themed gmail-SpellingErrorHighlight gmail-SCXW109579805 gmail-BCX0\">Benichou<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> S, <\/span><span class=\"gmail-NormalTextRun gmail-SpellingErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">Jauvin<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> D, De <\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Serres-B\u00e9rard<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> T, Pierre M, Ling KK, Bennett CF, et al. Antisense oligonucleotides as a potential treatment for brain deficits <\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">observed<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> in myotonic dystrophy type 1. Gene <\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Ther<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">. 2022 Dec;29(12):698\u2013709.<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> Available from: <\/span><\/span><a class=\"gmail-Hyperlink gmail-SCXW109579805 gmail-BCX0\" title=\"https:\/\/www.nature.com\/articles\/s41434-022-00316-7\" href=\"https:\/\/www.nature.com\/articles\/s41434-022-00316-7\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"gmail-TextRun gmail-Underlined gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">https:\/\/www.nature.com\/articles\/s41434-022-00316-7<\/span><\/span><\/a><span class=\"gmail-EOP gmail-SCXW109579805 gmail-BCX0\">\u00a0<\/span><\/em><\/p>\n<\/div>\n<div class=\"gmail-OutlineElement gmail-Ltr gmail-SCXW109579805 gmail-BCX0\">\n<p class=\"gmail-Paragraph gmail-SCXW109579805 gmail-BCX0\"><em><span class=\"gmail-TextRun gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Overby SJ, Cerro-Herreros E, <\/span><span class=\"gmail-NormalTextRun gmail-SpellingErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">Llamusi<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> B, <\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Artero<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> R. RNA-mediated therapies in myotonic dystrophy. Drug <\/span><span class=\"gmail-NormalTextRun gmail-SpellingErrorV2Themed gmail-SCXW109579805 gmail-BCX0\">Discov<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\"> Today. 2018 Dec;23(12):2013\u201322.<\/span><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">Available from: <\/span><\/span><a class=\"gmail-Hyperlink gmail-SCXW109579805 gmail-BCX0\" title=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1359644617305305\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1359644617305305\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"gmail-TextRun gmail-Underlined gmail-SCXW109579805 gmail-BCX0\" lang=\"EN-US\"><span class=\"gmail-NormalTextRun gmail-SCXW109579805 gmail-BCX0\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1359644617305305<\/span><\/span><\/a><span class=\"gmail-EOP gmail-SCXW109579805 gmail-BCX0\">\u00a0<\/span><\/em><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Myotonic dystrophy (DM) is a genetic disorder characterized by progressive muscle wasting causing two main problems: muscles that don\u2019t relax quickly (myotonia) and that gradually get weaker over time. It is a multi-system disorder, and symptoms can affect various organs and tissues, not just muscles. Performing daily activities can become challenging as this condition may [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":4702,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[48],"tags":[93,165,186,187],"class_list":["post-4504","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-patients","tag-disease-awareness","tag-genetic-testing","tag-myotonic-dystrophy","tag-dm1"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.5 (Yoast SEO v25.3.1) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>What is Myotonic Dystrophy - myTomorrows<\/title>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"ar_AR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What is Myotonic Dystrophy\" \/>\n<meta property=\"og:description\" content=\"Myotonic dystrophy (DM) is a genetic disorder characterized by progressive muscle wasting causing two main problems: muscles that don\u2019t relax quickly (myotonia) and that gradually get weaker over time. It is a multi-system disorder, and symptoms can affect various organs and tissues, not just muscles. Performing daily activities can become challenging as this condition may [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/main-portal.develop-mytomorrows.com\/ar\/blog\/patients\/what-is-myotonic-dystrophy\/\" \/>\n<meta property=\"og:site_name\" content=\"myTomorrows\" \/>\n<meta property=\"article:published_time\" content=\"2024-01-18T21:57:57+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-02-27T13:25:27+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/main-portal.develop-mytomorrows.com\/wp-content\/uploads\/2024\/01\/shutterstock_2363243407-e1705657089275.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1234\" \/>\n\t<meta property=\"og:image:height\" content=\"935\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"myTomorrows Team\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u0643\u064f\u062a\u0628 \u0628\u0648\u0627\u0633\u0637\u0629\" \/>\n\t<meta name=\"twitter:data1\" content=\"myTomorrows Team\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u0648\u0642\u062a \u0627\u0644\u0642\u0631\u0627\u0621\u0629 \u0627\u0644\u0645\u064f\u0642\u062f\u0651\u0631\" \/>\n\t<meta name=\"twitter:data2\" content=\"12 \u062f\u0642\u064a\u0642\u0629\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/main-portal.develop-mytomorrows.com\/ar\/blog\/patients\/what-is-myotonic-dystrophy\/\",\"url\":\"https:\/\/main-portal.develop-mytomorrows.com\/ar\/blog\/patients\/what-is-myotonic-dystrophy\/\",\"name\":\"What is Myotonic Dystrophy - myTomorrows\",\"isPartOf\":{\"@id\":\"https:\/\/main-portal.develop-mytomorrows.com\/ar\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/main-portal.develop-mytomorrows.com\/ar\/blog\/patients\/what-is-myotonic-dystrophy\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/main-portal.develop-mytomorrows.com\/ar\/blog\/patients\/what-is-myotonic-dystrophy\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/main-portal.develop-mytomorrows.com\/wp-content\/uploads\/2024\/01\/shutterstock_2363243407-e1705657089275.jpg\",\"datePublished\":\"2024-01-18T21:57:57+00:00\",\"dateModified\":\"2024-02-27T13:25:27+00:00\",\"author\":{\"@id\":\"https:\/\/main-portal.develop-mytomorrows.com\/ar\/#\/schema\/person\/41c113cd0050de2a6248b66a25f3d313\"},\"breadcrumb\":{\"@id\":\"https:\/\/main-portal.develop-mytomorrows.com\/ar\/blog\/patients\/what-is-myotonic-dystrophy\/#breadcrumb\"},\"inLanguage\":\"ar\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/main-portal.develop-mytomorrows.com\/ar\/blog\/patients\/what-is-myotonic-dystrophy\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"ar\",\"@id\":\"https:\/\/main-portal.develop-mytomorrows.com\/ar\/blog\/patients\/what-is-myotonic-dystrophy\/#primaryimage\",\"url\":\"https:\/\/main-portal.develop-mytomorrows.com\/wp-content\/uploads\/2024\/01\/shutterstock_2363243407-e1705657089275.jpg\",\"contentUrl\":\"https:\/\/main-portal.develop-mytomorrows.com\/wp-content\/uploads\/2024\/01\/shutterstock_2363243407-e1705657089275.jpg\",\"width\":1234,\"height\":935,\"caption\":\"Family with horse having fun. Happy father, mother and son caress horse outdoors on a farm ranch. Dad, mom and child. Animal love. Parent and kid cuddling animal pet at sunset. Soft focus on face.\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/main-portal.develop-mytomorrows.com\/ar\/blog\/patients\/what-is-myotonic-dystrophy\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/main-portal.develop-mytomorrows.com\/ar\/home\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"What is Myotonic Dystrophy\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/main-portal.develop-mytomorrows.com\/ar\/#website\",\"url\":\"https:\/\/main-portal.develop-mytomorrows.com\/ar\/\",\"name\":\"myTomorrows\",\"description\":\"Helping patients discover and access treatments\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/main-portal.develop-mytomorrows.com\/ar\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"ar\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/main-portal.develop-mytomorrows.com\/ar\/#\/schema\/person\/41c113cd0050de2a6248b66a25f3d313\",\"name\":\"myTomorrows Team\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ar\",\"@id\":\"https:\/\/main-portal.develop-mytomorrows.com\/ar\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/0bf0b2e36f36bbb195b2bb3735c1d7840b9f4e9bf56bee09bde37db6229842cd?s=96&d=blank&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/0bf0b2e36f36bbb195b2bb3735c1d7840b9f4e9bf56bee09bde37db6229842cd?s=96&d=blank&r=g\",\"caption\":\"myTomorrows Team\"},\"url\":\"https:\/\/main-portal.develop-mytomorrows.com\/ar\/blog\/author\/mytomorrows-team\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"What is Myotonic Dystrophy - myTomorrows","robots":{"index":"noindex","follow":"follow"},"og_locale":"ar_AR","og_type":"article","og_title":"What is Myotonic Dystrophy","og_description":"Myotonic dystrophy (DM) is a genetic disorder characterized by progressive muscle wasting causing two main problems: muscles that don\u2019t relax quickly (myotonia) and that gradually get weaker over time. It is a multi-system disorder, and symptoms can affect various organs and tissues, not just muscles. Performing daily activities can become challenging as this condition may [&hellip;]","og_url":"https:\/\/main-portal.develop-mytomorrows.com\/ar\/blog\/patients\/what-is-myotonic-dystrophy\/","og_site_name":"myTomorrows","article_published_time":"2024-01-18T21:57:57+00:00","article_modified_time":"2024-02-27T13:25:27+00:00","og_image":[{"width":1234,"height":935,"url":"https:\/\/main-portal.develop-mytomorrows.com\/wp-content\/uploads\/2024\/01\/shutterstock_2363243407-e1705657089275.jpg","type":"image\/jpeg"}],"author":"myTomorrows Team","twitter_card":"summary_large_image","twitter_misc":{"\u0643\u064f\u062a\u0628 \u0628\u0648\u0627\u0633\u0637\u0629":"myTomorrows Team","\u0648\u0642\u062a \u0627\u0644\u0642\u0631\u0627\u0621\u0629 \u0627\u0644\u0645\u064f\u0642\u062f\u0651\u0631":"12 \u062f\u0642\u064a\u0642\u0629"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/main-portal.develop-mytomorrows.com\/ar\/blog\/patients\/what-is-myotonic-dystrophy\/","url":"https:\/\/main-portal.develop-mytomorrows.com\/ar\/blog\/patients\/what-is-myotonic-dystrophy\/","name":"What is Myotonic Dystrophy - myTomorrows","isPartOf":{"@id":"https:\/\/main-portal.develop-mytomorrows.com\/ar\/#website"},"primaryImageOfPage":{"@id":"https:\/\/main-portal.develop-mytomorrows.com\/ar\/blog\/patients\/what-is-myotonic-dystrophy\/#primaryimage"},"image":{"@id":"https:\/\/main-portal.develop-mytomorrows.com\/ar\/blog\/patients\/what-is-myotonic-dystrophy\/#primaryimage"},"thumbnailUrl":"https:\/\/main-portal.develop-mytomorrows.com\/wp-content\/uploads\/2024\/01\/shutterstock_2363243407-e1705657089275.jpg","datePublished":"2024-01-18T21:57:57+00:00","dateModified":"2024-02-27T13:25:27+00:00","author":{"@id":"https:\/\/main-portal.develop-mytomorrows.com\/ar\/#\/schema\/person\/41c113cd0050de2a6248b66a25f3d313"},"breadcrumb":{"@id":"https:\/\/main-portal.develop-mytomorrows.com\/ar\/blog\/patients\/what-is-myotonic-dystrophy\/#breadcrumb"},"inLanguage":"ar","potentialAction":[{"@type":"ReadAction","target":["https:\/\/main-portal.develop-mytomorrows.com\/ar\/blog\/patients\/what-is-myotonic-dystrophy\/"]}]},{"@type":"ImageObject","inLanguage":"ar","@id":"https:\/\/main-portal.develop-mytomorrows.com\/ar\/blog\/patients\/what-is-myotonic-dystrophy\/#primaryimage","url":"https:\/\/main-portal.develop-mytomorrows.com\/wp-content\/uploads\/2024\/01\/shutterstock_2363243407-e1705657089275.jpg","contentUrl":"https:\/\/main-portal.develop-mytomorrows.com\/wp-content\/uploads\/2024\/01\/shutterstock_2363243407-e1705657089275.jpg","width":1234,"height":935,"caption":"Family with horse having fun. Happy father, mother and son caress horse outdoors on a farm ranch. Dad, mom and child. Animal love. Parent and kid cuddling animal pet at sunset. Soft focus on face."},{"@type":"BreadcrumbList","@id":"https:\/\/main-portal.develop-mytomorrows.com\/ar\/blog\/patients\/what-is-myotonic-dystrophy\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/main-portal.develop-mytomorrows.com\/ar\/home\/"},{"@type":"ListItem","position":2,"name":"What is Myotonic Dystrophy"}]},{"@type":"WebSite","@id":"https:\/\/main-portal.develop-mytomorrows.com\/ar\/#website","url":"https:\/\/main-portal.develop-mytomorrows.com\/ar\/","name":"myTomorrows","description":"Helping patients discover and access treatments","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/main-portal.develop-mytomorrows.com\/ar\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"ar"},{"@type":"Person","@id":"https:\/\/main-portal.develop-mytomorrows.com\/ar\/#\/schema\/person\/41c113cd0050de2a6248b66a25f3d313","name":"myTomorrows Team","image":{"@type":"ImageObject","inLanguage":"ar","@id":"https:\/\/main-portal.develop-mytomorrows.com\/ar\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/0bf0b2e36f36bbb195b2bb3735c1d7840b9f4e9bf56bee09bde37db6229842cd?s=96&d=blank&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/0bf0b2e36f36bbb195b2bb3735c1d7840b9f4e9bf56bee09bde37db6229842cd?s=96&d=blank&r=g","caption":"myTomorrows Team"},"url":"https:\/\/main-portal.develop-mytomorrows.com\/ar\/blog\/author\/mytomorrows-team\/"}]}},"_links":{"self":[{"href":"https:\/\/main-portal.develop-mytomorrows.com\/ar\/wp-json\/wp\/v2\/posts\/4504","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/main-portal.develop-mytomorrows.com\/ar\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/main-portal.develop-mytomorrows.com\/ar\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/main-portal.develop-mytomorrows.com\/ar\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/main-portal.develop-mytomorrows.com\/ar\/wp-json\/wp\/v2\/comments?post=4504"}],"version-history":[{"count":16,"href":"https:\/\/main-portal.develop-mytomorrows.com\/ar\/wp-json\/wp\/v2\/posts\/4504\/revisions"}],"predecessor-version":[{"id":5343,"href":"https:\/\/main-portal.develop-mytomorrows.com\/ar\/wp-json\/wp\/v2\/posts\/4504\/revisions\/5343"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/main-portal.develop-mytomorrows.com\/ar\/wp-json\/wp\/v2\/media\/4702"}],"wp:attachment":[{"href":"https:\/\/main-portal.develop-mytomorrows.com\/ar\/wp-json\/wp\/v2\/media?parent=4504"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/main-portal.develop-mytomorrows.com\/ar\/wp-json\/wp\/v2\/categories?post=4504"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/main-portal.develop-mytomorrows.com\/ar\/wp-json\/wp\/v2\/tags?post=4504"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}